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Published at www.nejm.org April 16, 2008 (10.1056/NEJMe0801414)

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Malaria, a tremendously successful pathogen that is responsible for more than 300 million cases and 1 million deaths annually,¹ has had a large impact on the shape of the human genome. Malaria-selected mutations in human genes promote survival in areas where malaria is endemic. The parasite's substantive effect on the human genome is due to its high prevalence in areas where it is endemic and its long history of coevolution with humans. Moreover, its marked genetic diversity, generated by its sexual stage, provides the organism with many opportunities to maximally adapt to host defenses and continue transmission. In this issue . . . [Full Text of this Article]

Source Information

From Brigham and Women's Hospital, Boston, and the Broad Institute, Cambridge, MA.

This article (10.1056/NEJMe0801414) was published at www.nejm.org on April 16, 2008. It will appear in the April 24 issue of the Journal.

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