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Published at www.nejm.org April 29, 2008 (10.1056/NEJMe0803046)

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Osteoporosis is a common skeletal disorder characterized by compromised bone strength and increased bone fragility, affecting up to 40% of postmenopausal women and 15% of men.¹ Its clinical significance lies in the occurrence of osteoporotic fractures — most commonly involving the forearm, the vertebral bodies, and the hip — with considerable morbidity, mortality, and cost to the individual and the community.²

Many factors, including age, menopausal status, smoking, physical activity, diet, coexisting diseases, and pharmacologic treatments, influence the risk of osteoporosis, but one of the most clinically important risk factors is a family history of the disorder. As in other . . . [Full Text of this Article]

Source Information

From the Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, and the Broad Institute of Harvard and MIT, Cambridge, MA (J.N.H.); the Department of Genetics, Harvard Medical School, Boston (J.N.H.); and the Department of Internal Medicine, University of Siena, Siena, Italy (L.G.).

This article (10.1056/NEJMe0803046) was published at www.nejm.org on April 29, 2008. It will appear in the May 29 issue of the Journal.

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