A Hopeful Beginning for Malaria Vaccines

doi:10.1056/NEJMe0808983

Published at www.nejm.org December 8, 2008 (10.1056/NEJMe0808983)

A Hopeful Beginning for Malaria Vaccines

William E. Collins, Ph.D., and John W. Barnwell, M.P.H., Ph.D.

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PubMed Citation

An effective human malaria vaccine has been sought for over70 years, with little success.¹ A successful malaria vaccineused in conjunction with other control interventions would helpreduce and eventually eliminate the considerable global diseaseburden caused by malaria. Many different antigens have beenidentified as potential targets for malaria-vaccine development.One of these, the repetitive sequence of four amino acids inthe circumsporozoite antigen on the surface of the sporozoiteof Plasmodium falciparum, arguably the most important of thehuman malarias, is the basis for the RTS,S vaccine.² This vaccinewas subjected to extensive studies involving human volunteers,. . . [Full Text of this Article]

Source Information

From the Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta. The opinions expressed in this article are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

This article (10.1056/NEJMe0808983) was published at www.nejm.org on December 8, 2008. It will appear in the December 11 issue of the Journal.