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Published at www.nejm.org April 1, 2009 (10.1056/NEJMe0902713)

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The optimal time to start antiretroviral therapy in asymptomatic patients has been one of the central controversies in the care of patients with the human immunodeficiency virus (HIV) since the introduction of the first antiretroviral agent, zidovudine, more than two decades ago.¹ Since then, periods of enthusiasm for aggressive early intervention² have been followed by a more cautious approach.³ This slowly swinging pendulum has been pushed back and forth by the extraordinary benefits of antiretroviral therapy on one side⁴ and emerging data on its adverse effects on the other.⁵

The absence of a controlled, prospective study comparing early and deferred . . . [Full Text of this Article]

Source Information

From the Division of Infectious Diseases and the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School — both in Boston.

This article (10.1056/NEJMe0902713) was published at NEJM.org on April 1, 2009. It will appear in the April 30 issue of the Journal.

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