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Published at www.nejm.org July 15, 2009 (10.1056/NEJMp0806848)

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On July 10, 2009, after an 18-month review, the Food and Drug Administration (FDA) approved the thienopyridine prasugrel for use in patients with unstable angina or myocardial infarction who undergo percutaneous coronary intervention (PCI). The new drug is the latest addition to a class of agents that inhibit the platelet adenosine diphosphate (ADP) receptor, preventing initial platelet activation and consequent platelet aggregation — a mechanism that has represented a major advance in the treatment of atherothrombotic diseases.¹ Indeed, the use of the thienopyridine ticlopidine in combination with aspirin to inhibit platelet aggregation facilitated the widespread use of coronary-artery stenting. Because . . . [Full Text of this Article]

Source Information

From the Department of Cardiology at the Veterans Affairs (VA) Boston Healthcare System and the integrated interventional cardiovascular program at Brigham and Women's Hospital and the VA Boston Healthcare System — both in Boston.

This article (10.1056/NEJMp0806848) was published on July 15, 2009, at NEJM.org.

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