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Published at www.nejm.org May 7, 2009 (10.1056/NEJMp0903906)

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Vast amounts of time and resources are being invested in planning for the next influenza pandemic, and one may indeed have already begun. Data from past pandemics can provide useful insights for current and future planning. Having conducted archeo-epidemiologic research, we can clarify certain "signature features" of three previous influenza pandemics — A/H1N1 from 1918 through 1919, A/H2N2 from 1957 through 1963, and A/H3N2 from 1968 through 1970 — that should inform both national plans for pandemic preparedness and required international collaborations.

Past pandemics were characterized by a shift in the virus subtype, shifts of the highest death rates to . . . [Full Text of this Article]

Source Information

Dr. Miller is the associate director for research, Dr. Viboud a staff scientist, and Dr. Balinska a research associate at the Fogarty International Center of the National Institutes of Health, Bethesda, MD. Dr. Simonsen is an adjunct professor and research director of the Department of Global Health, George Washington University School of Public Health and Health Services, Washington, DC.

This article (10.1056/NEJMp0903906) was published at NEJM.org on May 7, 2009. It will appear in the July 2 issue of the Journal.

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