Despite a plethora of diagnostic and treatment options, practicalinformation that can guide health care choices for an individualpatient are often elusive, and the resultant clinical uncertaintyis an important factor driving regional variations in clinicalpractice. Clinicians and patients need to know not only thata treatment works on average but also which interventions workbest for specific types of patients. Comparative patient-centeredinformation is essential to translating new discoveries intobetter health outcomes, accelerating the application of beneficialinnovations, and delivering the right treatment to the rightpatient at the right time.1
From the Department of Health and Human Services, Washington, DC (P.H.C., C.C.); Cincinnati Children's Hospital Medical Center, Cincinnati (P.H.C.); and the Agency for Healthcare Research and Quality, Rockville, MD (C.C.).
This article (10.1056/NEJMp0905631) was published on June 30, 2009, at NEJM.org.
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