Derivation of Embryonic Stem-Cell Lines from Human Blastocysts
Chad A. Cowan, Ph.D., Irina Klimanskaya, Ph.D., Jill McMahon, M.S., Jocelyn Atienza, B.S., Jeannine Witmyer, Ph.D., Jacob P. Zucker, B.S., Shunping Wang, Ph.D., Cynthia C. Morton, Ph.D., Andrew P. McMahon, Ph.D., Doug Powers, Ph.D., and Douglas A. Melton, Ph.D.
Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.
Embryonic stem cells have the unique ability to form all adultcell types. Harnessing this potential may provide a source ofcells to replace those that are lost or impaired as a resultof disease. Moreover, the derivation of human embryonic stemcells opens a unique window into the study of early human development.At present, approximately 15 human embryonic stem-cell linesare publicly available, and they vary considerably in theirusefulness for research and the extent of their characterization(see http://stemcells.nih.gov/registry/index.asp). To promotefurther research with human embryonic stem cells, we soughtto derive and characterize more fully . . . [Full Text of this Article]
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From the Howard Hughes Medical Institute (C.A.C., I.K., J.M., J.A., J.P.Z., D.A.M.) and the Department of Molecular and Cellular Biology (C.A.C., I.K., J.M., J.A., J.P.Z., A.P.M., D.A.M.), Harvard University, Cambridge, Mass.; Boston IVF, Waltham, Mass. (J.W., S.W., D.P.); and the Department of Obstetrics, Gynecology, and Reproductive Biology and Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston (C.C.M.). This article was published at www.nejm.org on March 3, 2004.
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