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(The original article is not available online.)

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Volume 355:221 July 13, 2006 Number 2

Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial

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 by Bresalier, R. S.
Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial . In the reported results, the test for proportionality of hazards used linear time rather than the logarithm of time that was specified in the Methods section. Analysis using the logarithm of time leads to the following changes:

The first complete paragraph on page 1097 should have read, "In a post hoc assessment, visual inspection of Figure 2 suggested that the Kaplan–Meier curves separated 18 months after randomization. However, the results of an overall test of the proportional-hazards assumption for the entire 36-month observation period did not reach statistical . . . [Full Text of this Article]


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