New England Journal of Medicine

Fiscal Responsibility and Health Care Reform

Levine, R. A. — 2009-08-26T13:56:56-07:00

(No abstract is available for this citation)

Setbacks and Fissions -- Reconsidering the Scope and Timing of Reform

Iglehart, J. K. — 2009-08-26T13:57:27-07:00

(No abstract is available for this citation)

The Tragedy of the Commons Revisited

Fadul, R. — 2009-08-26T13:55:43-07:00

(No abstract is available for this citation)

Health Care Reform and Clinical Culture

Ropper, A. H. — 2009-08-26T13:56:15-07:00

(No abstract is available for this citation)

Pandemic Influenza Vaccine Policy -- Considering the Early Evidence

Neuzil, K. M. — 2009-09-10T15:06:55-07:00

(No abstract is available for this citation)

Response after One Dose of a Monovalent Influenza A (H1N1) 2009 Vaccine -- Preliminary Report

2009-09-10T15:07:25-07:00

Background A novel influenza A (H1N1) 2009 virus is responsible for the first influenza pandemic in 41 years. A safe and effective vaccine is urgently needed. A randomized, observer-blind, parallel-group ...

Trial of Influenza A (H1N1) 2009 Monovalent MF59-Adjuvanted Vaccine -- Preliminary Report

2009-09-10T15:07:54-07:00

Background The 2009 pandemic influenza A (H1N1) virus has emerged to cause the first pandemic of the 21st century. Development of effective vaccines is a public health priority.

Methods We ...

HIV Vaccine Trial Results -- An Opening for Further Research

Dolin, R. — 2009-10-20T01:40:59-07:00

(No abstract is available for this citation)

A Novel Influenza A (H1N1) Vaccine in Various Age Groups

2009-10-21T13:58:42-07:00

Background There is an urgent need for a vaccine that is effective against the 2009 pandemic influenza A (H1N1) virus.

Methods A split-virus, inactivated candidate vaccine against the 2009 H1N1 ...

Primary Care and Accountable Care -- Two Essential Elements of Delivery-System Reform

Rittenhouse, D. R., Shortell, S. M., Fisher, E. S. — 2009-10-29T13:24:14-07:00

(No abstract is available for this citation)

The Emergency Use Authorization of Peramivir for Treatment of 2009 H1N1 Influenza

Birnkrant, D., Cox, E. — 2009-11-03T08:05:38-08:00

(No abstract is available for this citation)

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

2009-11-09T14:58:22-08:00

Background The development of a safe and effective vaccine against the human immunodeficiency virus type 1 (HIV-1) is critical to pandemic control.

Methods In a community-based, randomized, multicenter, double-blind, placebo-controlled ...

Emergence of Oseltamivir-Resistant Pandemic H1N1 Virus during Prophylaxis

Baz, M., Abed, Y., Papenburg, J., Bouhy, X., Hamelin, M.-E., Boivin, G. — 2009-11-11T13:52:15-08:00

(No abstract is available for this citation)

Controlling U.S. Health Care Spending -- Separating Promising from Unpromising Approaches

Hussey, P. S., Eibner, C., Ridgely, M. S., McGlynn, E. A. — 2009-11-11T13:51:32-08:00

(No abstract is available for this citation)

Getting to the Real Issues in Health Care Reform

Ginsburg, P. B. — 2009-11-11T13:51:54-08:00

(No abstract is available for this citation)

Narrowly Clearing the Next Hurdle -- Passage of the House Reform Bill

Iglehart, J. K. — 2009-11-11T13:52:40-08:00

(No abstract is available for this citation)

Dead Souls -- Comparing Dartmouth Atlas Benchmarks with CMS Outcomes Data

Langberg, M. L., Black, J. T. — 2009-11-11T13:53:04-08:00

(No abstract is available for this citation)

Looking beyond the Market

Levine, R. A. — 2009-11-11T13:51:08-08:00

(No abstract is available for this citation)

The HALTS Trial -- Halting Atherosclerosis or Halted Too Early?

Blumenthal, R. S., Michos, E. D. — 2009-11-15T15:48:12-08:00

(No abstract is available for this citation)

Statin Therapy with Ezetimibe or Niacin in High-Risk Patients

Kastelein, J. J.P., Bots, M. L. — 2009-11-15T15:48:35-08:00

(No abstract is available for this citation)

Deleterious Effects of Right Ventricular Pacing

Lindsay, B. D. — 2009-11-15T12:56:10-08:00

(No abstract is available for this citation)

Cangrelor -- A Champion Lost in Translation?

Kastrati, A., Ndrepepa, G. — 2009-11-15T04:50:49-08:00

(No abstract is available for this citation)

Biventricular Pacing in Patients with Bradycardia and Normal Ejection Fraction

2009-11-15T12:56:31-08:00

Background Observational studies suggest that conventional right ventricular apical pacing may have a deleterious effect on left ventricular function. In this study, we examined whether biventricular pacing is superior to ...

Extended-Release Niacin or Ezetimibe and Carotid Intima-Media Thickness

2009-11-15T15:48:57-08:00

Background Treatment added to statin monotherapy to further modify the lipid profile may include combination therapy to either raise the high-density lipoprotein (HDL) cholesterol level or further lower the low-density ...

Intravenous Platelet Blockade with Cangrelor during PCI

2009-11-15T04:51:40-08:00

Background Intravenous cangrelor, a rapid-acting, reversible adenosine diphosphate (ADP) receptor antagonist, might reduce ischemic events during percutaneous coronary intervention (PCI).

Methods In this double-blind, placebo-controlled study, we randomly assigned 5362 ...

Long-Term Outcome Associated with Early Repolarization on Electrocardiography

2009-11-16T12:59:00-08:00

Background Early repolarization, which is characterized by an elevation of the QRS-ST junction (J point) in leads other than V1 through V3 on 12-lead electrocardiography, has been associated with vulnerability ...

Anemia and Iron Deficiency -- New Therapeutic Targets in Heart Failure?

Dec, G. W. — 2009-11-17T04:51:04-08:00

(No abstract is available for this citation)

Rise of the Machines -- Left Ventricular Assist Devices as Permanent Therapy for Advanced Heart Failure

Fang, J. C. — 2009-11-17T04:51:28-08:00

(No abstract is available for this citation)

Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency

2009-11-17T04:51:57-08:00

Background Iron deficiency may impair aerobic performance. This study aimed to determine whether treatment with intravenous iron (ferric carboxymaltose) would improve symptoms in patients who had heart failure, reduced left ...

Platelet Inhibition with Cangrelor in Patients Undergoing PCI

2009-11-17T14:42:58-08:00

Background Cangrelor, a nonthienopyridine adenosine triphosphate analogue, is an intravenous blocker of the adenosine diphosphate receptor P2Y12. This agent might have a role in the treatment of patients who require ...

Advanced Heart Failure Treated with Continuous-Flow Left Ventricular Assist Device

2009-11-17T04:52:22-08:00

Background Patients with advanced heart failure have improved survival rates and quality of life when treated with implanted pulsatile-flow left ventricular assist devices as compared with medical therapy. New continuous-flow ...

Rapid-Test Sensitivity for Novel Swine-Origin Influenza A (H1N1) Virus in Humans

Blyth, C. C., Iredell, J. R., Dwyer, D. E. — 2009-11-18T14:10:15-08:00

(No abstract is available for this citation)

The Supreme Court, Process Patents, and Medical Innovation

Kesselheim, A. S. — 2009-11-18T14:11:50-08:00

(No abstract is available for this citation)

The Consequences of "No"

Kellermann, A. L., Lewin, L. S. — 2009-11-18T14:13:01-08:00

(No abstract is available for this citation)

Industry Influence on Comparative-Effectiveness Research Funded through Health Care Reform

Selker, H. P., Wood, A. J.J. — 2009-11-18T14:13:47-08:00

(No abstract is available for this citation)

Lobbying, Campaign Contributions, and Health Care Reform

Steinbrook, R. — 2009-11-18T14:12:19-08:00

(No abstract is available for this citation)

Health Care Reform -- A Republican View

Grassley, C. — 2009-11-18T14:14:15-08:00

(No abstract is available for this citation)

Eliminating a Viable Primary Care Workforce -- A Primary Care Perspective

Sterling, M. L. — 2009-11-18T14:10:50-08:00

(No abstract is available for this citation)

Antiviral Treatment for Patients Hospitalized with 2009 Pandemic Influenza A (H1N1)

Uyeki, T. — 2009-11-18T14:11:19-08:00

(No abstract is available for this citation)

Not "Socialized Medicine" -- An Israeli View of Health Care Reform

Chernichovsky, D. — 2009-11-18T13:56:32-08:00

In 2007, the United States spent about 15% of its gross domestic product (GDP) on health care, whereas Israel's health care spending was about 8% of its GDP (see graph, ...

Compromises and Controversies -- Moving Forward on Reform

Iglehart, J. K. — 2009-11-18T13:56:32-08:00

Accelerating progress toward the Democrats' goal of enacting health care reform legislation, House Speaker Nancy Pelosi (D-CA) unveiled a bill on October 29 that would establish a mandate for most ...

The American Public and the Next Phase of the Health Care Reform Debate

Blendon, R. J., Benson, J. M. — 2009-11-18T13:56:32-08:00

Congressional leaders and President Barack Obama are moving ahead to develop a single piece of major health care legislation, which will be debated, voted on by both houses of Congress, ...

Medicaid and National Health Care Reform

Rosenbaum, S. — 2009-11-18T13:56:32-08:00

Defined by a history of both achievement and controversy, Medicaid has once again become central to the U.S. health policy debate, this time figuring as a key to national health ...

Massachusetts Health Care Reform -- Near-Universal Coverage at What Cost?

Weissman, J. S., Bigby, J. — 2009-11-18T13:56:32-08:00

Massachusetts has long been known for its academic medical centers, biomedical research, high-quality health care, and perhaps not unrelatedly, high health care costs. In 2006, the state captured national attention ...

Mandatory Vaccination of Health Care Workers

Stewart, A. M. — 2009-11-18T13:56:32-08:00

Mandatory vaccination of health care workers raises important questions about the limits of a state's power to compel individuals to engage in particular activities in order to protect the public. ...

A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease

2009-11-18T13:56:32-08:00

Anemia is associated with an increased risk of cardiovascular and renal events among patients with type 2 diabetes and chronic kidney disease. This placebo-controlled trial randomly assigned such patients to receive darbepoetin alfa or placebo. The two composite end points were death or cardiovascular disease and death or end-stage renal disease. Darbepoetin alfa did not reduce either outcome and was associated with an increased risk of stroke.

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

2009-11-18T13:56:32-08:00

Genetic analyses showed that mutations affecting the interleukin-10 receptor are associated with early-onset colitis. Further molecular analyses showed that the mutations abrogated interleukin-10 signaling. Treatment of one of the affected children by means of allogeneic hematopoietic stem-cell transplantation was successful.

Combined Immunodeficiency Associated with DOCK8 Mutations

2009-11-18T13:56:32-08:00

This article describes a group of 11 patients between the ages of 6 and 21 years who had recurrent sinopulmonary infections, extensive cutaneous viral infections, severe allergies, and elevated serum levels of IgE; some of the patients also had asthma or reactive airway disease or susceptibility to cancer. All patients had loss-of-function mutations in the DOCK8 gene.

A Novel Protective Prion Protein Variant that Colocalizes with Kuru Exposure

2009-11-18T13:56:32-08:00

Kuru, a neurodegenerative disease associated with endocannibalism in Papua New Guinea, is the classic example of prion disease. Certain polymorphisms at codon 129 of the prion protein gene (PRNP) are highly associated with susceptibility to the development of kuru. In this report, further investigation involving kuru-exposed survivors in Papua New Guinea shows that certain polymorphisms in PRNP codon 127 lead to genetic resistance to kuru.

Mechanisms of Disease: Inflammatory Bowel Disease

Abraham, C., Cho, J. H. — 2009-11-18T13:56:32-08:00

This review gives an account of recent advances in our knowledge of the intestinal immune system and how it becomes perturbed in Crohn's disease and ulcerative colitis. The importance of genetic factors in these diseases has been increasingly recognized, and this article emphasizes their roles.

Air in the Portal and Mesenteric Veins

de Mendoza-Asensi, D., Planas, K. — 2009-11-18T13:56:32-08:00

A 73-year-old man with history of smoking, hypertension, chronic obstructive pulmonary disease, and type 2 diabetes mellitus presented with respiratory distress. The trachea was intubated, and the patient was admitted ...

Gouty Tophi

Wiesner, T., Fried, I. — 2009-11-18T13:56:32-08:00

A 77-year-old man presented with a 5-day history of painful swelling of his right elbow, which was also red, warm, and tender. When pressure was applied, a toothpastelike, white, chalky ...

Case 36-2009 -- A 23-Year-Old Man with Cough, Hoarseness, and Abnormalities on Chest Imaging

Choy, E., Digumarthy, S. R., Koplin, S. A. — 2009-11-18T13:56:32-08:00

A 23-year-old man was transferred to this hospital because of cough, hoarseness, fever, and abnormalities on chest imaging. One month before admission, a nonproductive cough developed, followed by hoarseness, dyspnea on exertion, and fever. Imaging studies at another facility showed pulmonary and mediastinal masses and a lesion in the pelvis. Positron-emission tomographic scans obtained at this hospital showed 18F-fluorodeoxyglucose-avid lesions. A diagnostic procedure was performed.

Treatment of Anemia in Chronic Kidney Disease -- Strategies Based on Evidence

Marsden, P. A. — 2009-11-18T13:56:33-08:00

Anemia associated with chronic kidney disease and end-stage renal disease is due, in large part, to reduced production of renal erythropoietin and abnormalities in extracellular-fluid volume homeostasis.1 Moreover, anemia and ...

Interleukin-10 in Inflammatory Bowel Disease

Kelsall, B. — 2009-11-18T13:56:33-08:00

In this issue of the Journal, Glocker et al.1 provide the first substantial support for a functional role for the immunosuppressive cytokine interleukin-10 in the pathogenesis of inflammatory bowel disease ...

The Hedgehog Pathway and Pancreatic Cancer

Hidalgo, M., Maitra, A. — 2009-11-18T13:56:33-08:00

Treatment of a mouse model of aggressive pancreatic cancer with an inhibitor of the hedgehog pathway enhanced tumor sensitivity to gemcitabine and resulted in the stabilization of disease.

Trials of Vertebroplasty for Vertebral Fractures

2009-11-18T13:56:33-08:00

To the Editor: In the August 6 issue, Kallmes et al.1 report on the Investigational Vertebroplasty Safety and Efficacy Trial ...

Apixaban or Enoxaparin for Thromboprophylaxis

2009-11-18T13:56:33-08:00

To the Editor: Lassen and colleagues (Aug. 6 issue)1 state that apixaban and enoxaparin had similar efficacy, based on the ...

Alpha1-Antitrypsin Deficiency

2009-11-18T13:56:33-08:00

To the Editor: In their Clinical Practice article (June 25 issue),1 Silverman and Sandhaus mention two small trials of augmentation ...

Cost Expansion versus Cost Control -- Lessons from the Canadian System

Liao, J., Choi, K. — 2009-11-18T13:56:33-08:00

The health care reform effort in the United States is driven by the desires for cost control and expanded coverage. However, as Daniel Callahan recently wrote, "cost controls that are ...

CME: A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease

2009-11-18T13:56:33-08:00

(No abstract is available for this citation)

CME: Inflammatory Bowel Disease

2009-11-18T13:56:33-08:00

(No abstract is available for this citation)

CME: Case 36-2009: A 23-Year-Old Man with Cough, Hoarseness, and Abnormalities on Chest Imaging

2009-11-18T13:56:33-08:00

(No abstract is available for this citation)