Multiple Complex Coronary Plaques in Patients with Acute Myocardial Infarction Acute myocardial infarction is believed to result from the rupture of a single unstable coronary plaque; however, the development of unstable plaques may be a widespread process. In this study, two fifths of the 253 patients with acute myocardial infarction had angiographic evidence of multiple complex coronary plaques, which are at risk for becoming unstable. As compared with patients with only one complex plaque, those with multiple complex plaques had a higher risk of recurrent acute coronary syndromes and a greater need for repeated angioplasty or for coronary bypass surgery during the following year.

Effect of Growth Hormone in Children with Chronic Renal Failure Children with chronic renal insufficiency have poor growth, and their short-term growth improves in response to growth hormone therapy. Whether treatment increases their adult height is not known, however. In 38 such children, who were treated with growth hormone for an average of 5.3 years starting at an average age of 10.4 years, the mean final height was increased by 1.4 SD over their standardized height at the start of treatment, and the majority of children achieved adult height within the normal range.

Liver Involvement in Hereditary Hemorrhagic Telangiectasia Patients with hereditary hemorrhagic telangiectasia have angiodysplastic lesions that affect many organs. This study examined the types of liver involvement in 19 patients with this disease. There were three distinct presentations: high-output heart failure, portal hypertension, and biliary disease.