In this large study of male physicians, bouts of vigorous physical exertion were associated with a transient increase in the risk of sudden death. This risk was attenuated, but not eliminated, if exercise was performed regularly. Despite the transient increase in risk with vigorous exertion, the absolute magnitude of the risk of sudden death during exertion was extremely small.

Adrenomedullary Dysplasia and Hypofunction in Patients with Congenital Adrenal Hyperplasia

The fact that adrenal medullary tissue is surrounded by adrenocortical tissue suggests that adrenal steroids contribute to the regulation of adrenal catecholamine secretion. In 38 children with congenital adrenal hyperplasia who were receiving appropriate replacement therapy, plasma epinephrine and metanephrine concentrations and urinary epinephrine excretion were low. Pathological examination of adrenal medullary tissue from three other patients revealed incomplete formation of the medulla, decreased amounts of tyrosine hydroxylase, and reduced numbers of secretory vesicles.

Human Herpesvirus 8 Infection in Men Who Have Sex with Men

Infection with human herpesvirus 8 (HHV-8) is associated with the development of Kaposišs sarcoma and appears to be sexually transmitted. HHV-8 was detected in mucosal samples from 30 of 50 HHV-8­seropositive men who had sex with men. The virus was present in 30 percent of the oropharyngeal samples but in only 1 percent of the anal and genital samples. The titers of HHV-8 were far higher in oropharyngeal samples than in other types of samples.

Human Herpesvirus 8 Infection and Marrow Failure after Transplantation About four months after receiving a kidney from the same cadaveric donor, who was seropositive for human herpesvirus 8 (HHV-8), one recipient presented with disseminated Kaposišs sarcoma and the other had an acute syndrome of fever and marrow failure. Primary HHV-8 infection was documented in both patients. HHV-8 infection may be associated with not only malignant, but also nonmalignant, complications in immunosuppressed hosts.