The New England Journal of Medicine
HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   HELP   |    Advanced Search
Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe
 
THIS WEEK
December 28, 2000
in the New England Journal of Medicine

 


Inhaled Triamcinolone and the Decline in Lung Function in COPD
graph This study addressed the question of whether regular use of inhaled triamcinolone slows the decline in lung function that occurs in patients with chronic obstructive pulmonary disease (COPD). The 1116 participants received either an inhaled corticosteroid or a placebo for a mean of 40 months. Although inhaled triamcinolone improved airway reactivity and respiratory symptoms, it did not slow the decline in lung function. Its use, however, was associated with a greater loss of bone mineral density.

Related Editorial

Genomic Aberrations and Survival in Chronic Lymphocytic Leukemia
Leukemic cells from 325 patients with chronic lymphocytic leukemia were examined for the presence of certain chromosomal abnormalities by fluorescence in situ hybridization. Abnormal chromosomes were found in 268 patients. Deletions in bands 17p and 11q correlated with poor prognosis, whereas a 13q deletion was associated with the longest survival.

Increases in Multidrug-Resistant Streptococcus pneumoniae
Strains of Streptococcus pneumoniae with resistance to antimicrobial agents have appeared in the United States. A program of surveillance for invasive disease due to S. pneumoniae found that the frequency of resistance to penicillin increased from 21 percent in 1995 to 25 percent in 1998. The frequency of resistance to three or more classes of drug increased from 9 percent to 14 percent, and this increase occurred exclusively among penicillin-resistant isolates.

Related Editorial

Antibiotics and the Density of Vancomycin-Resistant Enterococci in Stool
graphThis prospective study of patients colonized with vancomycin-resistant enterococci examined changes in the density of these organisms in stool in relation to treatment with antibiotics. The number of vancomycin-resistant enterococci in stool increased by a factor of more than 10 in 10 of 13 patients who began treatment with antianaerobic antibiotics, whereas overall, the density decreased slightly in 10 patients who received antibiotics with minimal antianaerobic activity.

Related Editorial

Outcome of Myocardial Infarction in Veterans Health Administration Patients as Compared with Medicare Patients

Some believe that the quality of care is not as high at Veterans Health Administration (VHA) hospitals as at other hospitals. This study found that, among older patients with acute myocardial infarction, 30-day and 1-year mortality rates were the same in VHA and non-VHA hospitals where Medicare patients were treated. However, the VHA patients had more coexisting conditions, such as hypertension, chronic obstructive pulmonary disease or asthma, and stroke.

This study refutes the belief that the quality of care, in this case for myocardial infarction, is inferior at VHA hospitals, as compared with non-VHA hospitals. Even though VHA patients as a group have a higher burden of coexisting illnesses than non-VHA patients, the mortality rate for this serious condition is the same as that among Medicare beneficiaries treated in non-VHA hospitals.

Related Editorial

HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  HELP  |  beta.nejm.org

Comments and questions? Please contact us.

The New England Journal of Medicine is owned, published, and copyrighted © 2008 Massachusetts Medical Society. All rights reserved.