Table of Contents

THIS WEEK
August 10, 2000
in the New England Journal of Medicine
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Neurologic and Developmental Disability after Extremely Preterm Birth

Neurologic and developmental examinations were performed at a median age of 30 months in 283 infants born at a gestational age of 25 weeks or less. These infants represented 92 percent of the surviving children in the United Kingdom and Ireland who were born at these gestational ages during 10 months in 1995. The study found that severe disability is common among children born preterm.
 


Stenting versus Thrombolysis

In patients with acute myocardial infarction, immediate restoration of coronary blood flow has important clinical benefits. This study compared two reperfusion strategies: thrombolysis with the tissue plasminogen activator alteplase and coronary stenting plus platelet glycoprotein IIb/IIIa receptor blockade with abciximab. As compared with thrombolytic therapy, stenting plus abciximab resulted in a greater degree of myocardial salvage and a better clinical outcome.
 


Sutures or Mesh for Repair of Incisional Hernia?

Incisional hernias are an important complication of abdominal surgery, and the optimal method of repair is not known. In this study, patients with incisional hernias were randomly assigned to undergo hernia repair with use of either sutures or mesh. The three-year cumulative rates of recurrence after repair of a primary hernia or a first recurrence were significantly lower with mesh repair (23 percent rate of recurrence) than with suture repair (46 percent rate of recurrence).

 


Separation of Conjoined Twins with the Twin Reversed-Arterial-Perfusion Sequence

Congenital anomalies associated with multifetal pregnancies include conjoined twinning and absence of the heart (acardia) in one twin fetus, whose blood supply comes from the other (cardiac) twin. Conjoined twins are usually separated several weeks or months after birth, whereas an acardiac twin is usually sacrificed in utero. In this case of a twin pregnancy in which the twins were conjoined and one had no heart, prenatal magnetic resonance imaging was used to plan the surgical separation, which was successfully accomplished immediately after birth.