In this randomized trial of the postoperative treatment of high-risk squamous-cell carcinoma of the head and neck, concurrent radiotherapy plus chemotherapy (cisplatin) reduced the incidence of local and regional recurrence and prolonged disease-free survival, as compared with radiotherapy alone. The combined treatment was substantially more toxic than radiotherapy alone.

This paper and the accompanying article by Bernier et al. (see page 1945) indicate that radiotherapy with concomitant cisplatin is a promising adjuvant treatment for locally advanced head and neck cancer.

This randomized trial of adjuvant treatment for locally advanced cancer of the head and neck compared radiotherapy alone with radiotherapy plus concomitant cisplatin after surgery with curative intent. Progression-free and overall survival were superior in the combined-therapy group.

This article and the accompanying article by Cooper et al. (see page 1937) indicate that radiotherapy with concomitant cisplatin is a promising adjuvant treatment for locally advanced head and neck cancer.

This hemodynamic study provides convincing evidence that heart failure in patients with a normal left ventricular ejection fraction is due to abnormal diastolic function.

The abnormalities in active relaxation and passive stiffness that were observed are sufficient to explain the elevated filling pressures and symptoms of heart failure in such patients and may provide targets for therapy.

In patients with Hurler's syndrome, cord-blood transplantation before the age of two years halts disease progression and prolongs life, but many children lack donors. This study reports complete donor chimerism and normal leukocyte -L-iduronidase levels in 17 of 20 children with Hurler's syndrome who received cord-blood transplants from unrelated donors. Their neurocognitive performance improved and somatic features decreased after transplantation.

Cord-blood transplantation favorably altered the natural history of Hurler's syndrome.

A 22-year-old woman presents to her gynecologist with genital lesions. Examination reveals bilateral labial ulcerations, cervical ulcerations, and mildly tender inguinal lymphadenopathy. To her knowledge, neither she nor any of the four sexual partners she has had, including her husband of two years, has ever had herpes. How should this patient's case be managed?

The most common cutaneous lymphoma is mycosis fungoides, a non-Hodgkin's, peripheral T-cell lymphoma. Recent advances in the understanding of the molecular and biologic behavior of T cells in this lymphoma — notably, their ability to home to the skin, function in an activated state, and achieve clonal dominance — have had a tremendous influence on current treatment. In this review, the expanding armamentarium of biologic agents, phototherapeutic and irradiation techniques, and combination regimens available to treat mycosis fungoides is discussed.

A 26-year-old woman with end-stage renal disease from primary membranoproliferative glomerulonephritis who had received her second cadaveric renal transplant 11 months previously presented with a 2-week history of intermittent fever, with temperatures as high as 39°C.