More than 30,000 participants were enrolled in a screening program for lung cancer based on spiral computed tomography. Stage I lung cancer was detected in 412 participants; their estimated 10-year survival rate after surgical resection was almost 90%.

Eleven patients with extensive pemphigus vulgaris that was resistant to conventional therapy had responses to a combination of rituximab plus intravenous immune globulin. After 6 months of this combined treatment, all 11 patients were in remission and required no therapy.

In a series of patients with venous thromboembolism who had been treated with anticoagulation for at least 3 months, D-dimer testing was performed 1 month after the discontinuation of anticoagulation. Patients with an abnormal D-dimer level were randomly assigned either to resume or to stop anticoagulation. The group resuming anticoagulation had a significantly lower rate of subsequent venous thromboembolism and major bleeding.

The authors show that three brothers with the severe phenotype of the Wiskott–Aldrich syndrome, who were described by Wiskott in 1937, were homozygous for a mutation in the WAS gene.

This article in the Medical Education series describes the problems with and success in trying to teach one of the core values of medicine, professionalism. As we better define professionalism, the authors say, it becomes easier to teach.

This review discusses the autoantibodies in pemphigus vulgaris and pemphigus foliaceus and the clinical and pathological similarities among these forms of pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome.

A 43-year-old man was evaluated as an outpatient for hypogonadism, new-onset diabetes, arthralgias, and fatigue. The patient was in his usual state of health until fatigue and decreased libido gradually developed 6 months before evaluation. An initial workup revealed hyperglycemia and elevated levels of liver enzymes and serum ferritin. A diagnostic procedure was performed.

Induction of the expression of a splicing protein reverses myotonia in a mouse model of myotonic dystrophy.

Lacerations are among the most common reasons for visits to emergency departments; over 11 million such wounds are treated each year in the United States. Although most lacerations will heal without treatment, laceration repair reduces infection, scarring, and patient discomfort. Various methods may be used to repair lacerations. This video demonstrates suturing, the most common method of wound closure.